The need and desire to recreate the structures of natural products by chemical synthesis have served as a continuous inspiration for scientists to drive the field of organic chemistry forward. The total synthesis of natural ...

The presented work focuses on the biosynthesis of fungal natural products. Structural analysis of phyllostictine A revealed the literature structure to be erroneous and led to the revised bicyclic 3-methylene tetramic ...

Immer neu auftretende Virusvarianten oder die Entstehung multiresistenter Bakterien stellen eine enorme Herausforderung in der heutigen Medizin dar. Die Biodiversität der Natur bietet ein großes Reservoir für die Entdeckung ...

The main focus of the presented work concentrated on understanding and engineering the biosynthesis of three polyketides produced by filamentous fungi: squalestatin S1, strobilurin A and SCH–642305. In a combined genetic ...

Novel high-throughput cultivation techniques create a demand to pre-select strains for in-depth follow-up studies. We report a workflow to identify promising producers of novel natural products by systematically characterizing ...

Aspergillus oryzae is traditionally used in East Asia for the production of food and brewing. In addition, it has been developed into a suitable host for the heterologous expression of natural product biosynthetic genes ...

In order to render potent, but toxic antibiotics more selective, we have explored a novel conjugation strategy that includes drug accumulation followed by infection-triggered release of the drug. Bacterial targeting was ...

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